Chromosomal abnormalities alterations and aberrations are at the root of many inherited diseases and traits. Approximately 70 of human conceptions fail to achieve viability with almost 50 of all pregnancies ending in miscarriage before the clinical recognition of a missed period or the presence of embryonal heart activity Edmonds et al.
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The American College of Obstetricians and Gynecologists ACOG has developed guidelines that provide recommendations on screening for fetal chromosomal abnormalities.
How to detect chromosomal abnormalities in pregnancy. Chromosomal abnormalities often give rise to birth defects and congenital conditions. Unlike other chromosomal abnormalities which are more likely to occur in moms with certain risk factors such as those who are 35 years or older or who have a family history of a genetic disorder microdeletions seem to occur randomly which means they dont usually run in families and equally affect any baby regardless of other risk factors. Spontaneous pregnancy loss is the most common complication of pregnancy.
1988Recurrent pregnancy loss RPL or recurrent.
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